Therapeutic properties of human immunoglobulin. Immunoglobulin human: instructions for use.

pharmachologic effect

The preparation is an immunologically active protein fraction containing a broad spectrum of antibodies isolated from blood plasma from donors tested for the absence of antigen and antibodies to human immunodeficiency virus (HIV-1 and HIV-2), hepatitis C virus and hepatitis B surface antigen. Active component of the drug is immunoglobulin G, which has the activity of antibodies of different specificity. The drug also has nonspecific immunoregulatory activity, which manifests itself in increasing the body's resistance and anti-inflammatory action. The drug is devoid of anticomplementary properties.

Pharmacokinetics

With intravenous infusion, bioavailability is 100%. C max antibodies in the blood are stored up to 14 days. T 1/2 antibody from the body is 4-5 weeks. The drug passes through the placenta and penetrates into breast milk.

Indications

- treatment of severe forms of bacterial and viral infections;

- treatment of postoperative complications, accompanied by bacteremia and septicopyemic conditions;

- primary syndrome of antibody deficiency - agamma and hypogammaglobulinemia (congenital form, period of physiological deficit in newborns);

- secondary antibody deficiency syndrome;

- blood diseases, consequences of immunosuppressive therapy, acquired immunodeficiency syndrome (AIDS), especially when infecting children with human immunodeficiency virus.

Dosing regimen

Immunoglobulin for infusion is used only in a hospital. Before administration, the vials are kept at a temperature of (20 ± 2) ° C for at least 2 hours. Muddy and sediment-free solutions are not applicable.

The dose and the frequency of administration of the drug depend on the indications for use. For children, a single dose of the drug is 3-4 ml per 1 kg of body weight, but not more than 25 ml. The speed of infusion and the duration of therapy are selected individually by the physician.

Immediately prior to administration, the drug is diluted with 0.9% sodium chloride solution or 5% glucose solution at the rate of: 1 part of the preparation and 4 parts of the diluent. The diluted immunoglobulin is administered intravenously at a drop rate of 8-10 drops per minute. Infusion is carried out daily for 3-5 days. For adults, a single dose of the drug is 25-50 ml. Immunoglobulin (without additional dilution) is administered intravenously drip at a rate of 30-40 drops per minute.

The course of treatment consists of 3-10 transfusions, conducted in 24-72 hours (depending on the severity of the disease).

Side effect

Reactions to the introduction of immunoglobulin, as a rule, are absent. Local adverse reactions are skin hyperemia at the injection site. During the first day after the administration of the drug, an increase in temperature up to 37.5 ° C, allergic reactions up to anaphylactic shock are possible.

In a number of cases (less than 1 in 100 prescriptions), headache, dizziness, dyspeptic phenomena, abdominal pain, arterial hypo- or hypertension, tachycardia, cyanosis, dyspnea occur.

Rare adverse reactions - a marked decrease in blood pressure, collapse, loss of consciousness, chills, myalgia.

Contraindications

- Allergic reactions or severe systemic reactions to blood products of a person in the anamnesis;

- in cases of severe sepsis, the only contraindication is an anaphylactic shock against a person's blood products in an anamnesis;

- immunodeficiency of IgA.

Carefully:   severe heart failure, diabetes, kidney failure, pregnancy, lactation.

Application in pregnancy and lactation

With caution in pregnancy and lactation.

Use in children

It is possible to use according to the indications according to the dosing regimen.

Overdose

Cases of drug overdose are not described.

Drug Interactions

Therapy with immunoglobulin can be combined with other drugs, in particular, antibiotics.

The introduction of immunoglobulins can weaken (during 1.5-3 months) the action of live vaccines against such viral diseases as measles, rubella, mumps and chickenpox (vaccinations with these vaccines should be given no earlier than 3 months). After the administration of large doses of immunoglobulin, its effect can last in individual cases up to one year. Do not use concomitantly with calcium gluconate in infants.

Conditions of leave from pharmacies

On prescription.

Terms and conditions of storage

The drug is stored in a dry, dark place at a temperature of 2 to 8 ° C. The drug should be stored in places inaccessible to children. Transportation is carried out by any kind of covered transport at a temperature of 2 to 8 ° C. Shelf life - 1 year.

Application for violations of kidney function

With caution in kidney failure.

special instructions

Introduction of immunoglobulin and preventive vaccinations.

Treatment with immunoglobulin drugs reduces the effectiveness of vaccination, so vaccinations are conducted no earlier than 2-3 months after the administration of immunoglobulin.

Persons with allergic diseases (bronchial asthma, atopic dermatitis, recurrent urticaria) or prone to allergic reactions on the day of immunoglobulin administration and for the next 8 days are recommended to prescribe antihistamine drugs. In the period of aggravation of the allergic process, the drug is administered by the conclusion of an allergist.

Persons suffering from autoimmune diseases (blood diseases, connective tissue, nephritis, etc.) should be given the drug on the background of appropriate therapy.

Immunoglobulin penetrates into breast milk and can facilitate the transfer of protective antibodies to the newborn.

Temporary elevation of antibodies in the blood after administration leads to false-positive analysis results in a serological study (Coombs reaction).

After the administration of the drug, the patient should be monitored for at least 30 minutes. In the room where the drug is administered, there should be antishock therapy. With the development of anaphylactoid reactions, antihistamines, glucocorticosteroids and adrenomimetics are used. At pregnancy enter only under strict indications when the prospective benefit for the mother exceeds the potential risk for the fetus.

Normal human immunoglobulin   Is a drug-preventive drug, which is classified as a group of immunostimulating and immunomodulating agents. It is produced from the blood of healthy donors who have undergone special clinical examinations and laboratory tests and have no evidence of blood-borne infections (in particular, HIV infections, hepatitis C and B).

The main component of this preparation is the immunologically active fraction of the blood protein, which is predominantly represented by immunoglobulin G and contains immunoglobulin M and immunoglobulin A in small concentrations. The preparation is thoroughly purified, concentrated and viral inactivated during manufacturing. Normal human immunoglobulin does not contain preservatives and antibiotics, as a stabilizer contains glycine.

Form release and method of using normal human immunoglobulin

The medication can be produced in the form of a solution, packaged in ampoules, or as a lyophilizate for making a solution, packaged in bottles. In liquid form it is colorless or yellowish, transparent. The lyophilisate of a normal human immunoglobulin is a porous hygroscopic white mass. The human immunoglobulin is used for intramuscular (injections) and intravenous (dropper) administration.

Properties of normal human immunoglobulin

The drug has the properties of immunoglobulin G, which is available in healthy people. When it is introduced, the following effects are achieved:

  • replenishment of missing IgG antibodies, which helps to reduce the risk of developing various infections;
  • resumption of low IgG level to normal values;
  • increased non-specific resistance of the human body;
  • suppression and neutralization of a wide range of bacteria, viruses and other infectious agents.

Indications for the use of normal human immunoglobulin:

  • congenital antibody deficiency syndrome;
  • general variable immunodeficiency;
  • iatrogenic immunodeficiency;
  • chronic lymphocytic leukemia;
  • myeloma;
  • thrombocytopenic purpura of an immune origin with an increased risk of bleeding;
  • kawasaki's disease;
  • bone marrow transplantation;
  • severe infections of various origins;
  • bacterial meningitis;
  • guillain-Barre syndrome;
  • demyelinating inflammatory polyneuropathy in chronic form;
  • hemolytic anemia;
  • thrombocytopenia of an immune origin;
  • autoimmune neutropenia;
  • partial red cell aplasia of hematopoiesis;
  • recurrent spontaneous miscarriage;
  • hepatitis A;
  • measles;
  • polio;
  • flu;
  • whooping cough;
  • meningococcal infections, etc.

Immunoglobulins, antibodies or gamma globulins are specific proteins distributed in human blood that are produced by the immune system to specifically protect the body against the effects of various viruses, bacteria and foreign substances.

The drug "Normal human immunoglobulin"

The human immunoglobulin is a medicament composition based on blood components of healthy donors - plasma. Donors should be clinically examined. The blood given by them should pass laboratory research. It will show that this material has no signs of infectious diseases that can be transmitted with and its components.

It is an immunomodulating and immunostimulating substance. Due to the content of neutralizing antibodies in its composition, it actively resists various attacks of viruses and bacteria. By its properties, the drug "Normal human immunoglobulin" practically does not differ from the type G present in tissue fluids, in secrets that produce mucous membranes of a person, etc. This comprehensive body protection, named - It performs its work in the liquid media of the human body.

There is also cellular immunity, which is carried out by specialized cells, but this is a completely different defense, and it has nothing to do with immunoglobulins. In addition to the above properties, "Normal human immunoglobulin" has a general strengthening and anti-inflammatory effect.


In what cases are immunoglobulin prescribed?

This medicine is prescribed to replace or replenish natural human antibodies. The main indications for its introduction are various states of the human body, when its own defense is extremely weakened. Such pathologies include:

  1. Bone marrow transplantation.
  2. Primary and secondary immunodeficiencies.
  3. Severe viral and bacterial diseases, etc.

The medicine "Human immunoglobulin is normal" works positively. Reviews about it are numerous and contradictory in a variety of infections, inflammatory-chronic diseases. In addition, this drug helps to increase oppressed immunity under the influence of medications.


The use of immunoglobulin intravenously

Do injections of a drug that increases immunity, can be both intramuscular and intravenous. He is prescribed for various complications after operations, accompanied by sepsis, multiple sclerosis, as well as for preventive actions and treatment of infectious complications in newborns, etc. It is in these cases that the medication "Normal human immunoglobulin" is administered. The intravenous method of drug administration in these cases is the most effective. Instruction for the use of the preparation describes the basic principles by which the treatment itself, which is prescribed by the attending physician, taking into account all indications, the severity of the diseases, the state of the patient's immune system and individual intolerance, is directly performed. To enter the medicine, you need a dropper and saline solution. The concentration of human immunoglobulin can be from 3 to 12 percent.


Intra-muscular injection of immunoglobulin

Ampoules must be conditioned before use for 2 hours. Their opening and direct administration of the drug should be carried out with strict adherence to the rules of antiseptics.

There are other ways to introduce the patient the medication "Immunoglobulin normal". A person can be intramuscularly injected with this medicine for emergency prevention of measles and hepatitis A, pertussis, poliomyelitis, etc. The drug is injected into the upper outer square of the gluteus muscle or to the external surface of the thigh. The medicine is not stored in an open ampoule, it must be destroyed.

Also, immunoglobulin can not be used in ampoules, in which the integrity is broken and marking is not visible. In no case should the intramuscular form of the drug be injected into the vein of the patient, and vice versa. Treatment and dosage is prescribed by the doctor strictly individually. Experts take into account the type and severity of the disease, only after that they make appointments.

Immunoglobulins are used for the preparation of preventive vaccination formulations. They are not necessary to confuse them with the vaccine, they are various components.


Side effects of the drug "Normal human immunoglobulin"

With proper use of this drug, the occurrence of side effects occurs extremely rarely. Sometimes such symptoms can occur after several hours or even days after the administration of the medication. And all the side effects disappear after the immunoglobulin of a normal person ceases to be introduced into the body. 25 ml intravenously - the dose of an adult patient by drop method. Sometimes the amount can reach 50 ml. In general, the emergence of all side effects is associated with a high infusion rate of the drug. At a low rate of administration and with the complete cessation of the use of immunoglobulin, all signs of side effects decrease and disappear. During the first hour, the following states may appear:

  1. Chills.
  2. Malaise.
  3. Headache.
  4. Heat.
  5. Sore joint, weakness.

In addition, there may be some symptoms from the side:

  1.   cough and shortness of breath.
  2. Digestive: pain in the gastrointestinal tract, diarrhea, nausea.
  3. Cardiovascular system: a rush of blood to the face, tachycardia.
  4. Central nervous system: photosensitivity, drowsiness.

Among other things, the drug "Immunoglobulin normal human" can cause various allergic reactions - itching, burning, skin rash. The most dangerous, but very rare phenomenon - necrosis of the renal tubules - necrosis. Severe hypertension and loss of consciousness require complete discontinuation of the drug. It should also be remembered that any injection of human immunoglobulin can cause allergic reactions, even if all previous injections have gone without complications.


Immunoglobulin during pregnancy

With caution this drug is used during lactation, as it is known that immunoglobulin penetrates into the mother's milk and can facilitate the transfer of protective antibodies to the infant. Assign immunoglobulin to a normal person during pregnancy only if there is a threat of miscarriage in a future mother or premature birth. Sometimes the drug is prescribed for an infection that threatens the life of the mother or fetus. Each question about the administration of this drug is solved with an individual approach and on the basis of numerous analyzes. Although there is no data on the adverse effects of immunoglobulin on the fetus or reproductive capacity, this drug is used for pregnant women only in case of emergency.

Contraindications for the introduction of immunoglobulin

Immunoglobulin preparations reduce the effect of administering live vaccines, such as measles, rubella, chickenpox, if they were made within 1.5-3 months. Therefore it is very important after the application of immunoglobulin graft repeat. The drug "Normal human immunoglobulin", whose price ranges from 2,200 to 2,600 rubles, can not be administered to patients with intolerance to blood components. Assign it only after consulting with doctors for heart dysfunctions, diabetes, kidney disease, migraine, pregnancy and lactation. In case of an overdose of this medication, side effects may increase. There is also an increase in the level of viscosity of blood and its volume.


Where can I buy it?

The drug can be produced in two forms: in the form of a dry powder and a solution that is contained in vials. This drug, that is, "Normal human immunoglobulin", the price of which is very different and depends on the manufacturer, the form of release and many other factors, is purchased only in pharmacy stores. It must necessarily be accompanied by instructions for use. Use of medicine without prescribing a doctor is prohibited, since there is a high risk of various side effects.

Storage conditions

Keep the drug in a dry, dark, inaccessible place for children, perhaps even in the refrigerator. The storage temperature is 2-10 degrees Celsius. It is not recommended to freeze this medication. must be indicated on the package. At the expiration of the drug to use is not suitable. Before using human immunoglobulin, it is always necessary to consult your doctor.

Immunoglobulin human (human immunoglobulin normal) is an immunological drug replenishing the missing IgG antibodies, which reduces the risk of developing infectious diseases in patients with immunodeficiency (both primary and secondary).

Form of issue and composition

Dosage forms of human immunoglobulin:

  • Solution for the / m introduction, in ampoules of 1, 1.5 and 3 ml;
  • Solution for intravenous administration, in bottles for blood substitutes of 25 and 50 ml.

The active substance of the drug is human immunoglobulin, which is an immunoglobulin fraction isolated from human plasma, then purified and concentrated. In 1 ml of the solution for IV infusion, its concentration is 50 mg, in 1 dose of the solution for the / m administration - 1 ml, 1.5 ml or 3 ml.

Indications for use

Intramuscularly, human immunoglobulin is prescribed to increase the nonspecific resistance of the body during immunosuppressive therapy, during convalescence, as well as in weakened patients.

In addition, in / m the drug is used for emergency prevention:

  • Meningococcal infection;
  • Pertussis;
  • Poliomyelitis.
  • Corey;
  • Hepatitis A;
  • Rubella in the first trimester of pregnancy in non-immune patients and in women with unknown immune status.

Intravenous Immunoglobulin is indicated when:

  • Diseases of the blood;
  • Diseases of Kawasaki;
  • The consequences of immunosuppressive therapy;
  • Chronic lymphocytic leukemia;
  • Guillain-Barre Syndrome;
  • Idiopathic thrombocytopenic purpura;
  • Multiple sclerosis;
  • Primary immunodeficiency;
  • Hyperimmunoglobulinemia syndrome E;
  • Eaton-Lambert Syndrome;
  • Dermatomyositis;
  • Acquired Immunodeficiency Syndrome (HIV);
  • Agamma and hypogammaglobulinemia (primary antibody deficiency syndrome), including congenital form and physiological deficit in newborns;
  • Secondary antibody deficiency syndrome;
  • Infections, the causative agent of which is parvovirus B19;
  • Chronic inflammatory demyelination with polyneuropathy;
  • Dermatomyositis;
  • Severe forms of viral and bacterial-toxic infections, including postoperative complications, accompanied by sepsis or bacteremia.

In the complex treatment of Immunoglobulin, a human is prescribed for long-term illnesses that are difficult to cure antibiotic therapy.

To prevent infections, the drug can be used for bone marrow transplantation, as well as for newborns, children with low birth weight and premature babies.

Contraindications

Immunoglobulin is contraindicated in:

  • Hypersensitivity to human immunoglobulins;
  • Allergic and / or severe systemic reactions to human blood products in history;
  • Exacerbations of allergies;
  • Immunodeficiency IgA.

With caution, the drug is used for diabetes mellitus, renal and severe heart failure, during lactation and pregnancy.

In cases of development of severe sepsis, the only contraindication to human immunoglobulin is an anaphylactic shock in history due to the administration of blood products.

Dosing and Administration

The drug is used only in a hospital.

  • Intramuscular application of human immunoglobulin.

For the prevention of measles no later than 4 days after contact with a sick person: children from 3 months, not measles and not vaccinated, once injected 1.5 or 3 ml, adults - once 3 ml.

For the prevention of poliomyelitis in unvaccinated or not fully vaccinated children prescribe 3-6 ml once as soon as possible after contact with the patient with a paralytic form of the disease.

For the prevention of hepatitis A, children older than 10 years and adults are administered 3 ml, children 7-10 years - 1.5 ml, children 1-6 years - 0.75 ml once. If necessary, repeated administration, but not earlier than 2 months.

For the prevention and treatment of influenza is shown a single administration of Immunoglobulin: children older than 7 years and adults - 4.5-6 ml, children 2-7 years - 3 ml, children under 2 years - 1.5 ml. In severe forms of influenza, a second injection is made 24-48 hours later.

For the prevention of whooping cough in unaffected children is shown a 2-fold introduction of 3 ml at intervals of 24 hours.

For the prevention of meningococcal infection no later than 7 days after contact with the patient with a generalized form of infection, children from 6 months to 3 years are administered 1 ml, children from 4 years - 3 ml.

  • Intravenous application of human immunoglobulin.

A single dose for adults is 25-50 ml. Children dosage is calculated based on weight - 3-4 ml / kg, but not more than 25 ml.

At least 2 hours the vials are kept at room temperature. Immediately before administration, the immunoglobulin is diluted with 5% glucose solution or 0.9% NaCl solution in a 1: 4 ratio.

The diluted drug is injected intravenously at a rate of 8-10 drops / minute. The course of treatment - 3-10 infusions with intervals of 1-3 days. It is possible to use the solution in its pure form, but in this case it is injected at a speed of no more than 40 cap / min.

Children are only allowed to drip IV infusion. Duration of treatment is 3-5 days.

Specific doses, the frequency of administration and the duration of treatment are determined by the physician individually for each patient, taking into account the indications.

Side effects

Basically, the drug is well tolerated, in the first day there may be a slight increase in body temperature (up to 37.5 ºC).

In some cases (not more than 1 patient out of 100), there are:

  • Dizziness and headache, incl. migraine;
  • Abdominal pain, nausea and / or vomiting, diarrhea;
  • Fluctuations of blood pressure, tachycardia and cyanosis;
  • Shortness of breath, a feeling of constriction or pain in the chest;
  • Hyperemia at the injection site.

In individual cases, back pain, fever or cold sensation, malaise, increased sweating, marked decrease in blood pressure, chills, myalgia, acute necrosis of renal tubules, aseptic meningitis, allergic reactions, up to anaphylactic shock are possible.

Too rapid IV administration of the preparation is fraught with the development of a collapoid reaction.

special instructions

At least 30 minutes after IV infusion the patient should be under the supervision of a doctor. The room must be provided with anti-shock therapy.

Solution Immunoglobulin human for intramuscular injection is categorically prohibited from intravenous administration.

Temporary increase of antibodies in the blood after injection leads to false positive results of serological examination.

Immunoglobulin can weaken the action of live vaccines against rubella, measles, chicken pox and mumps. For this reason, vaccinations against these diseases are made no earlier than 3 months after treatment with Ig.

In some cases, after the administration of large doses of the drug, its effect can last up to a year.

Breast children should not be prescribed human immunoglobulin in combination with calcium gluconate.

Analogues

  • Synonyms: Gamimun N, Gabriglobin, Gabriglobin-IgG, IG Vienna NIIV, Gamunex, Intraglobin, Immunovenin, Intetect, Imbioglobulin, Octagam, Phlebogamma 5%, Priwidgen;
  • Analogues: Immunoglobulin complex preparation, Gistasseroglobulin, Pentaglobin and Immunoglobulin, enriched with human IgM.

Terms and conditions of storage

Store Human immunoglobulin is necessary at a temperature of 2-8 ºC. Do not freeze! Shelf life - 1 year.

Immunoglobulin human normal has in the composition the active substance - immunoglobulin fraction. It is initially released from human plasma, after which it is purified and concentrated. As a part of the preparation, there is no human immunodeficiency virus and hepatitis C viruses, it does not contain it. The protein concentration is 4.5% -5.5%. Low anticomplementary activity of the drug is noted.

Form of issue

Immunoglobulin preparations are available in two forms. It is a solution for intramuscular injection and a dry powder for infusion (Immunoglobulin IV). A solution is a clear or slightly opalescent liquid without color.

pharmachologic effect

This medicine has immunostimulating   and immunomodulating act . It contains many opsonizing and neutralizing antibodies. Their presence provides effective resistance to bacteria, viruses and a number of other pathogens.

Under the influence of this remedy, the amount of missing IgG antibodies is replenished. As a result, the risk of developing infection in people diagnosed with primary and secondary is reduced. Immunoglobulin replaces and replaces natural antibodies in human blood serum.

To understand the essence of the effect on the body of this drug, it is necessary to understand how the immunoglobulin functions in the human body, what it is. Wikipedia testifies that immunoglobulins are unique immune molecules that can neutralize a number of toxins and many pathogens in the human body.

To neutralize a specific type of virus or bacteria, the body produces unique types of immunoglobulins. There is a classification according to which classes of immunoglobulins are determined depending on antigenic features, properties, and structure.

If necessary, a blood test for immunoglobulin, general and specific. Such a survey makes it possible to determine whether allergic diseases   and appoint the right treatment. The expert can determine the results of the analysis in detail, determining whether the immunoglobulin is elevated (the norm of its content depends on the person's age). If a certain class is upgraded, what this means is explained in detail by the specialist.

Pharmacokinetics and pharmacodynamics

In carrying out intravenous infusion   the bioavailability level is 100%. The highest concentration of antibodies in human blood is observed for 14 days. The half-life of antibodies is 4-5 weeks. It penetrates the placenta and enters the breast milk.

Indications for use

A normal human immunoglobulin is indicated as a substitution treatment if the patient needs to undergo a substitution treatment to replace and replenish natural antibodies.

In order to prevent infections, it is prescribed in the following cases:

  • when carrying out a bone marrow transplant;
  • with agammaglobulinemia;
  • in the case of primary and secondary immunodeficiency, with variable immunodeficiency;
  • at , which has a chronic character;
  • with children;
  • with thrombocytopenic purpura, which has an immune origin;
  • in severe bacterial and viral infections;
  • with Kawasaki Syndrome;
  • guillain-Barre Syndrome;
  • with erythrocytic aplasia;
  • with neutropenia, which is of autoimmune origin;
  • with demyelinating polyneuropathy of chronic type;
  • with hemolytic anemia and thrombocytopenia, having an autoimmune origin;
  • at , provoked and caused by the synthesis of antibodies to the factor P;
  • in the treatment of myastenia gravis;
  • with the aim of preventing habitual ;
  • for the prevention of infectious diseases in premature newborns.

Contraindications

The following contraindications for the use of this drug are determined:

  •   to human immunoglobulins;
  • igA deficiency due to the presence of antibodies to it;
  •   in acute form;
  •   on blood products.

When appointing a remedy, it is necessary to take into account not only contraindications, but also those conditions and diseases in which treatment should be conducted with caution.

Very cautiously appointed remedy for people suffering, decompensated heart failure   chronic nature, and pregnant women , mothers in the period of natural feeding . With care and only after the appointment of a doctor, people suffering from diseases whose origin is associated with immunopathological mechanisms ( collagenosis , nephritis , immune diseases of the blood ).

Side effects

If the patient is prescribed Immunoglobulin normal, and the correct treatment regimen, dosage and administration characteristics are followed, then the expressed side effects are rare. However, it should be noted that side effects can occur within hours or even days after the drug has been injected. In most cases, negative manifestations completely disappear after the drug has been discontinued.

In general, the side effects are observed due to too high a rate of infusion of the drug. If you temporarily suspend the introduction or reduce its speed, then most of the negative effects will disappear. If the negative symptoms persist, it is necessary to practice symptomatic treatment.

Most often, adverse events are observed when Immunoglobulin is administered to a person for the first time, moreover, it develops within the first hour. It can be the following symptoms:

  • influenza-like syndrome ( fever , chills , weakness );
  • , ;
  • vomiting, strong salivation, pain in the stomach;
  • , cyanosis , flushes of blood to the face, painful sensations in the chest;
  • weakness , sensitivity to light, disturbances of consciousness, in rare cases - signs of aseptic ;
  • in rare cases acute tubular necrosis manifests, the condition in people with renal insufficiency may worsen;
  • allergic reactions ;
  • local reactions.

In addition to the above symptoms, there may be a feeling of aches in the joints, myalgia , sweating , backache. Very rarely there is a loss of consciousness, collapse , hypertension in severe form. If the response to therapy is very serious, you must cancel the treatment. If necessary, you can enter, antihistamines, solutions that replace the plasma.

Instructions for use Immunoglobulin (Method and dosage)

Instruction for Immunoglobulin provides the possibility of drip intravenous and intramuscular administration of the drug. As a rule, the dose of the drug is prescribed individually, taking into account the severity of the disease, condition, etc.

Instructions for the use of medicines for children include the introduction of 3-4 ml of funds for 1 kg of the child's weight, with the dose should not exceed 25 ml. Before the introduction of Immunoglobulin, 0.9% solution of sodium chloride (sterile) or 5% glucose solution, respectively, 1 part of the drug and 4 parts of the solvent. Drip intravenously is introduced, while the speed should be 8-10 drops per minute. Infusions are carried out within 3-5 days.

Adult patients receive a single dose of 25-50 ml. Dilute additionally the drug is not required, injected intravenously, while the rate of administration is 30-40 drops per minute. The course of treatment is assigned 3-10 transfusions, which are conducted after 24-72 hours.

If there is a question where to put a dropper, it should be noted that the drug can be injected intravenously only in the hospital, while it is important to strictly comply with the requirements of aseptic. Where it is possible to make an injection of Immunoglobulin, you can find out in the nearest medical institution. It is also possible to obtain information on the conditions under which Immunoglobulin is administered to children free of charge.

Before you enter the product, the bottle should be kept at a temperature of 18 to 22 ° C for at least 2 hours. If the solution is cloudy or there is a sediment in it, it can not be injected.

Overdose

There may be signs of an overdose of the drug when administered intravenously. Such symptoms are hypervolemia   and high blood viscosity . It is more likely that overdose symptoms occur in the elderly and in patients with kidney disease.

Interaction

The pharmaceutical incompatibility of the drug with other medicines is noted. It should not be confused with other drugs, you should always use a separate dropper for Immunoglobulin.

The effectiveness of the drug may decrease if it is administered at the same time as the immunization medication at, at, at.

If there is a need to apply parenterally live virus vaccines with chickenpox, etc., they can be used 1 month after treatment with Immunoglobulin, but it is advisable to withstand a break for 3 months.

Do not use the product at the same time as in the treatment of infants.

Terms of sale

In pharmacy chains sold on prescription.

Storage conditions

It is necessary to transport and store the preparation accordingly with SP 3.3.2.038-95, temperature regime - 2-8 ° C. You can not freeze.

Shelf life

Shelf life 1 year. Can not be applied after the expiration of this period.

special instructions

Patients who are diagnosed with diseases whose origin is associated with immunological mechanisms can use Immunoglobulin only after consulting a doctor who is treating these diseases.

The introduction of the medicine must be registered in the appropriate registration form, in which it is necessary to indicate the series, number, date of manufacture, expiration date, date of administration, dosage and response to receipt of the drug.

Do not use the drug if the container with it was damaged. After opening the container, the medicine is used in the same section, it can not be stored open.

The protective effect of the drug is noted after 24 hours and lasts for 30 days.

After the application of Immunoglobulin, a passive increase in the amount of antibodies in the blood is noted. Therefore, when the blood is given for analysis, the transcription of the blood test for immunoglobulin can later be incorrect.

Patients who are diagnosed with allergic diseases   or noted tendency to allergic manifestations , should receive antihistamines on the day of administration of the solution and for eight days after it is received.

After the drug was administered to the patient, it is necessary to observe it for another half an hour. The specialist should have access to funds for anti-shock therapy.

Analogues

Matches by ATC code of 4th level:

In medicine, a number of analogues of this remedy are used. These are drugs Hamunex , Immunovinin , Intraglobin , , Intratect , Gabriglobin , Endobulin   and etc.

To choose an adequate analogue, one should understand what is Immunoglobulin and always consult with a doctor. To determine which particular drug will be the most optimal for the treatment or prevention of diseases, for example, Immunoglobulin   or for prevention tick-borne encephalitis , it is necessary to consult with a specialist.

Children

You can prescribe the drug to children in the presence of indications, while it is important to follow the dosage described in the instructions clearly.

With alcohol

Immunoglobulin and alcohol are incompatible, since alcohol is an immunosuppressant, it worsens the functioning of the human immune system. When you drink alcohol on the background of treatment with this drug, the probability of side effects increases sharply. In addition, diseases and conditions requiring the appointment of Immunoglobulin, imply a categorical ban on the use of alcohol.

Immunoglobulin during pregnancy and lactation

Information on the damage caused by the appointment of a remedy for pregnant   absent. However, intravenous injection or injection of Immunoglobulin during pregnancy are performed only if there are clear indications.

Discussing the effectiveness of Immunoglobulin, women leave the responses different, noting that the drug can alleviate the condition with many diseases, in particular with, etc. When using the drug, it is practiced cautiously, as it enters the breast milk and ensures the transmission of antibodies to the infant. Women after the birth of the drug is administered if there is evidence.

Loading ...Loading ...