A remedy for kidneys is nitroxoline. Dosages and duration of treatment of various diseases. "Nitroxoline"

In most cases, the cause of diseases are microbes and fungi of various types. They live in any organism and in small amounts of serious harm can not cause health. But with the slightest disruption in the normal functioning of the immune system, pathogenic microbes begin to multiply actively, which can be fraught with serious problems. Nitroxoline is indicated for use just in cases when the disease was provoked by the activity of microbes, fungi or other harmful microorganisms.

Indications for the use of Nitroxoline tablets

To date, Nitroxoline is considered one of the best drugs with a strong antimicrobial effect. The product has a wide spectrum of action, it can be used to treat absolutely different diseases for both children and adults.

The wide use of Nitroxoline is completely justified. The drug works very effectively, without causing harm to health. The principle of the drug is very simple: Nitroxoline inhibits the multiplication of cells of pathogenic microbes, affecting them with a special enzyme complex. By themselves, without multiplying, the cells live a short life and die.

And do not worry: Nitroxoline treatment does not harm healthy cells of the body at all. Due to the special composition, the agent can act solely on pathogenic cells, without touching the normal vital.

Nitroxoline is indicated for use in the following cases:

1. This is an excellent tool for the treatment of infectious diseases that affect the genito-urinary organs:

cystitis;
urethritis.

2. To the stronger sex, Nitroxoline helps in the fight against:

prostatitis;
adenoma;
epididymitis and other unpleasant diseases.

3. Often the drug is used for carcinomas.

4. Nitroxoline is used not only for treatment, but also for preventive purposes. Many specialists prescribe medication to people:

who underwent operations on the genitourinary tract and kidneys;
for the prevention of complications of an infectious origin.

Some doctors prefer Nitroxoline to other drugs in the treatment of acute viral diseases, such as, for example, influenza, bronchitis. Really effective treatment can be only if the disease is caused by a microbe or a bacterium. Therefore, before starting Nitroxoline, it is recommended that you consult with a specialist.

Dosage and Administration Nitroxoline

So far, there is only one dosage form of Nitroxoline - in tablets. They are intended for internal reception. All tablets are covered with a sweet shell of yellow and orange. The active substance in the drug - nitroxoline - in each tablet is contained in an amount of 50 mg.

The course of treatment is selected individually. The duration of it depends on the overall picture of the disease and the patient's state of health. In general, it is recommended to take two tablets four times a day. The maximum daily dose of the drug for an adult person should not exceed 0.8 grams, for a child - half as much. The traditional course of treatment lasts two to three weeks. Even if the disease has not receded, re-treatment can be done only a couple of weeks after the first course.

Nitroxoline treatment of cystitis

For tablets Nitroxoline is the number one remedy. If they encountered the disease for the first time, it is recommended to drink the drug according to the usual scheme - four times a day - but it is desirable to observe equal intervals for taking tablets. Nitroxoline is needed every four hours - in this case, the effect of the drug will be maximum.

The minimum course is two weeks. Even if the symptoms disappear earlier, stop drinking pills can not.

Nitroxoline is an antibacterial drug.

Composition and form of release

Nitroxoline is released in the form of tablets coated with a film membrane. Each tablet contains 50 mg of the main active ingredient, nitroxoline. For 10 tablets in contour cell packs.

Pharmacological action Nitroxoline

According to the instructions, Nitroxoline is an antimicrobial drug derived from 8-hydroxyquinoline. Nitroxoline is active against:

gram-negative bacteria: Shigella spp., Escherichia coli, Enterobacter spp., Neisseria gonorrhoeae, Salmonella spp., Proteus spp., Klebsiella spp .;
gram-positive bacteria: Staphylococcus spp., Streptococcus spp., Bacillus subtilis, Bacillus subtilis;
Mycobacterium tuberculosis, Trichomonas vaginalis, as well as some species of fungi, including Candida spp., Mold, dermatophytes and pathogens of deep mycoses.

After applying Nitroxoline, it is rapidly absorbed from the digestive tract. The drug is excreted by the kidneys unchanged.

Indications for use

Indications for Nitroxoline according to the instructions are the following states:

Diseases of the genitourinary tract of an infectious-inflammatory nature (, carcinoma or infected prostate, etc.) caused by microorganisms sensitive to Nitroxoline;
Prevention of infections during medical and diagnostic manipulations (cystoscopy, catheterization), as well as in the postoperative period after surgical interventions on the genitourinary tract and kidneys.

Dosing and Administration

According to the instruction, Nitroxoline is prescribed to adults in a dosage of 600-800 mg per day, divided into 3-4 doses. The interval between doses of the drug should not be less than 6-8 hours. Duration of treatment - two weeks. The maximum dosage per day is 1-1.2 g.

Nitroxoline dosage for children is 10-30 mg / kg of body weight divided into 3-4 doses.

With persistent recurrent and chronic infections, the duration of treatment can be several months.

Nitroxoline according to the instructions are taken one hour before a meal, with a full glass of water. It is necessary to strictly adhere to the regimen of treatment with indications for Nitroxoline, do not skip the medication. If nevertheless the pill reception was missed, it is necessary to take it as soon as possible, and if it is time to take the next pill, then the dose should not be doubled.

If no improvement occurs during the course of Nitroxoline therapy for several days, it is necessary to consult a doctor about the drug discontinuation.

Side effect of Nitroxoline

According to reviews, Nitroxoline can cause the following adverse reactions:

Skin rashes and itching (reactions);
and nausea, loss of appetite, occasionally - violations of the liver (digestive system);
(the cardiovascular system);
Headache, paresthesia, polyneuropathy (peripheral and central nervous system).

According to reviews, Nitroxoline for prolonged use can cause neuritis of the optic nerve.

Contraindications

According to the instructions Nitroxoline is contraindicated:

With a shortage of glucose-6-phosphate dehydrogenase;
If the kidney function is violated, followed by anuria or oliguria;
Against the backdrop of severe liver disease;
During pregnancy and lactation;
With neuritis,;
Against a background of hypersensitivity to nitroxoline or quinoline preparations.

special instructions

It should be borne in mind that during the intake of Nitroxoline urine is painted in a yellow-orange color.

Terms and conditions of storage

Nitroxoline belongs to the list B preparations with a recommended shelf life of 4 years.

LSR-008832/08

Trade name of the preparation:

NITROXOLINE

INN or grouping name:

nitroxoline

Dosage form:

coated tablets

Composition:

each tablet contains
active substances: 50 mg of nitroxoline;
Excipients: lactose (sugar milk), potato starch, silicon dioxide colloid (aerosil), talc, calcium stearate, polysorbate-80 (tween 80) - a sufficient amount to obtain a tablet weighing 100 mg (without shell); sugar (sucrose), magnesium hydroxycarbonate, povidone (polyvinylpyrrolidone low molecular weight medical), silicon dioxide colloid (aerosil), talc, titanium dioxide, tropeoline O, azorubin (acidic red 2C for pharmaceutical purposes), beeswax - to obtain a tablet with a coating weight 200 mg.

Description:
The tablets covered with a cover of light orange or orange color, round, biconcave. On the fracture are visible three layers: internal - from yellow to grayish-yellow color, a slightly greenish tint is permissible; Medium - white and outer - from light orange to orange.

Pharmacotherapeutic group:

antimicrobial agent - oxyquinoline.

ATX Code: J01XX07

Pharmacological properties

Antimicrobial agent of a wide spectrum of action. Nitroxoline selectively inhibits the synthesis of bacterial DNA and has an effect on both gram-positive microorganisms: Staphylococcus spp. (including S. aureus), Streptococcus spp. (including beta-hemolytic streptococci, Streptococcus pneumoniae, Enterococcus faecalis), Corynebacterium diphtheriae, Bacillus subtilis; and on gram-negative microorganisms: N.gonorrhoeae, E. coli, Proteus spp., Klebsiella spp., Salmonella spp., Shigella spp., Enterobacter spp. Nitroxoline is also active against Mycobacterium tuberculosis, Trichomonas vaginalis, certain species of fungi (Candida spp., Dermatophytes, molds, some pathogens of deep mycoses). Pharmacokinetics Absorption is high. It is excreted by the kidneys unchanged, with a high concentration in the urine (100 μg / ml and more).

Indications for use

Infectious and inflammatory diseases mainly of the genitourinary tract (including pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or carcinoma of the prostate, etc.) caused by micro-organisms sensitive to nitroxoline. Prevention of infectious complications in diagnostic and therapeutic manipulations (catheterization, cystoscopy) in the postoperative period with surgical interventions on the kidney and urinary tract.

Contraindications

Impaired renal function, accompanied by oligo- or anuria; severe liver disease; deficiency of glucose-6-phosphate dehydrogenase; children's age to three years (taking into account the solid indivisible dosage form), cataracts, neuritis, polyneuritis, pregnancy (III trimester), lactation. Hypersensitivity to quinoline preparations.

Dosing and Administration

The drug is taken orally. For adults, the daily dose is 400-800 mg. Multiplicity 3-4 times a day with an interval of 6-8 hours. The course of treatment is 2-3 weeks. In chronic infections of the urinary tract, the drug can be given again for 2 weeks with a 2-week break. The average daily dose for children older than 5 years is -0.2-0.4 g (by 0.05-0.1 g 4 times a day), under 5 years -0.2 g per day. For the prevention of infections in kidney and urinary tract surgery appoint 0.1 g per reception 4 times a day for 2-3 weeks. Children are prescribed in a daily dose of 10-30 mg / kg in 3-4 divided doses.

Side effect

Sometimes nausea, vomiting, loss of appetite, very rarely skin allergic reactions are possible. In rare cases - tachycardia, ataxia, headache, paresthesia, polyneuropathy, liver dysfunction. With prolonged use, the case of the development of neuritis of the optic nerve is described.

special instructions

During treatment, urine is colored in saffron-yellow color.

Form of issue

Coated tablets, 50 mg.
10 tablets per contour cell pack.
50 tablets per can of polymeric materials.
For 5 contour packs or 1 can of polymeric materials, together with instructions for medical use, put in a pack of cardboard.

Storage conditions

Store in a dry, dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.

Shelf life

4 years. After the expiration of the drug does not apply.

Conditions of leave from pharmacies

Let go on prescription.

Producer / organization accepting claims
OOO Anzhero-Sudzhensky Chemical and Pharmaceutical Plant.
652473, Russia, Kemerovo Region, Anzhero-Sudzhensk, ul. Herzen, 7.

It is known that microorganisms are able to penetrate practically into any tissues of the body and cause an infectious process there. Anti-microbial medications such as antibiotics, sulfonamide preparations, antifungal or antiprotozoal agents, quinoline derivatives, and others are prescribed to control them.

The leading place among all inflammatory diseases of the organs of the urinary tract is cystitis (the mucosa of the bladder is affected). With the timely administration of antimicrobials, the disease can be managed as soon as possible.

Nitroxoline in cystitis is widely prescribed by therapists and urologists, since the drug is effective against most known pathogens and at the same time has a low cost. It has proven effective in therapy in both women and men.

What is Nitroxoline?

The remedy has been on the Russian market for more than 50 years and during this time has been widely recommended both among doctors and among patients. Nitroxoline is known not only in our country, but also in the countries of the near abroad.

Nitroxoline has a fairly wide range of its pharmacological action, and the proven resistance to it develops extremely rarely. In medicine, he took his "niche" in the practice of urologists, although with the same efficiency it can be prescribed in the treatment of bronchitis or pneumonia, provided that these processes are caused by sensitive microorganisms. After taking the drug, it very quickly enters the bloodstream, is filtered by the kidneys, and then completely concentrated in the urine, where its therapeutic effect on the affected organs of the urinary tract occurs.

The mechanism of action of the drug is to suppress the synthesis of microbial DNA, which disrupts the process of natural cell division and leads to their accelerated death. Nitroxoline exerts its destructive effect on the following pathogens: enterococci, Escherichia coli, streptococci, Klebsiella, Staphylococcus, Proteus, Salmonella and others.

The preparation is produced only in tablet form. Tablets have a shell of yellow-orange hue.

When do you prescribe the drug and how do you take it?

Nitroxolin has found its application in infections of the urinary tract:

inflammatory process in the renal-pelvic apparatus (pyelonephritis), in the epithelium of the bladder (cystitis), in the walls of the urethra (urethritis), in men with pathology in the appendages of the testicles (epididymitis) or in the treatment of inflammation in the tumor of the prostate;
with the preventive purpose the drug can be used before the forthcoming diagnostic procedure (for example, cystoscopy), which will allow the patient to avoid possible complications after it.

These instructions for use are provided for informational purposes only, after all, before starting treatment of the disease, it is necessary to consult a doctor. Only an expert will tell you how to take the drug, set individual treatment terms, and most importantly, will conduct a thorough dynamics of the process under the control of laboratory and instrumental data.

Standard dosage regimens:

In acute first-time conditions, Nitroxoline in a dose of 100 mg is taken every 6 hours for 10-14 days (it is very important to observe the same time interval).
If the drug is administered from a cystitis in a chronic and often recurrent form, the same time interval remains, but the dose of the drug increases (150-300 mg per single dose) and the duration of treatment (sometimes the therapy lasts several months with short breaks).

Cancellation occurs only after all the symptomatology is completely stopped, and urinalysis and blood tests are normalized (at least 3 trials are performed at different intervals).

The treatment is conducted under the control of blood and urine tests, due to which the effectiveness of therapy is evaluated

The medicine should not be chewed. During treatment it is recommended to drink more pure water. Each tablet should be washed with at least 200 ml of liquid. Since the drug is able to cause a slight feeling of nausea and a decrease in appetite, it is best to take it while eating.

Can Nitroxoline be taken during pregnancy and in childhood?

The question of whether it is possible to take this medicine for pain in the kidney or cystitis that have arisen during pregnancy should be decided only by a gynecologist. To date, the toxic effect of the drug on the fetus has not been established, if to follow strict recommendations and the timing of its admission during gestation.

In children's practice, the medicine has proved its safety, since its excretion occurs through the kidneys, completely bypassing the liver and all metabolic transformations. Therefore, its appointment is recommended from the age of three months of the baby's life.

Gynecologists prescribe the drug in II and in the first weeks of the third trimester of pregnancy, when the risk of possible complications is minimal

Contraindications

If the patient has the following conditions, Nitroxoline is strictly contraindicated:

decompensated kidney failure with a sharp decrease in the volume of daily urine (less than 500 ml) or with its full delay (anuria);
decompensated hepatic insufficiency;
a stomach ulcer or duodenal ulcer in acute form;
severe form of senile cataract;
neuritis of the facial or trigeminal nerve;
established sensitivity to any components of the drug;
age less than 3 months.

With caution it is taken with hepatic-renal failure of mild or moderate severity.

Side effects

Among the most common adverse reactions to taking the drug should be:

on the part of the digestive tract (nausea, vomiting, deterioration of appetite);
an allergic reaction (itching and redness of the skin, rashes like hives);
nervous system (periodic headaches, disorders of the sensitive sphere, with prolonged admission, it is possible to defeat the oculomotor nerve);
from the heart (increased heartbeat).

Do not get scared when, at the time of treatment, the patient is staining urine or feces in saffron, and sometimes red. After the termination or ending of therapy this phenomenon completely passes or takes place.

Why can Nitroxoline not help?

If you understand all the possible reasons for the inadequate effect of the drug, it becomes clear that the vast majority of the causes are due to "human" factors, namely:

the initial intake of the drug in inadequately low doses (this applies to both doses and multiplicity of use);
a short course of treatment, that is, an independent refusal of further therapy for a number of reasons (for example, the patient became better, and he stopped treatment, or wrapped, and the other has no money);
most often women who have not been explained that the drug does not immediately have its effect, stop taking it the next day, so they wait for the result "from the first doses".

Before you refuse treatment with Nitroxoline in its ineffectiveness, make sure that you strictly follow all instructions, and do not make a series of mistakes

In conclusion, it must be said that any medication should be agreed with the attending physician. This will save you from possible complications, or the transition of pathological processes into a chronic form. Only a specialist will answer the question of why the kidneys are aching or other symptoms of impaired urination occur, which means that only he knows whether you are showing the purpose of this medication or not.

Have you been diagnosed with cystitis? To date, pharmacies are represented by many drugs that will help fight this disease, and one of them is Nitroxoline. It has been used in urology for more than ten years and has proved effective in practice.

Nikctoxoline is an antibiotic or not?

Doctors prescribe patients this drug in order to eliminate inflammation in the urinary tract. Many people do not want to take antibiotics and when they prescribe this medicine, they have a question - to what category does it apply?

You do not have to worry, the drug does not apply to antibiotics. Nevertheless, despite this, he copes well with microbes and infections, so that the cystitis treatment passes quickly and easily. Nitroxoline more gently affects the body and, unlike antibiotics, not a violation of the microflora of the stomach and intestines.

Indications for admission Nitroxolin:

Diseases of the urinary, genital tract, which occur under the influence of infections and microorganisms
Infected adenoma
Inflammation of the prostate
Epididymitis
Restoration of the functionality of the genitourinary system after surgery

How does the medicine work? Substances that are in its composition, block pathogenic microorganisms, as a result of all the infected cells die. Thus, the drug blocks the further spread of the disease. In this case, substances do not affect healthy cells and tissues, which helps to avoid complications.

Dosage

If you need to cure cystitis, take 4 tablets twice a day, the duration of treatment is two weeks. If you have a neglected form of the disease, increase the dosage to 6 tablets, the duration of treatment is 3 weeks.

In any case, you should be guided by dosage. In a day you can take no more than 800 mg of the drug, divide it into 2-3 admission. Even if you have improvements, do not stop taking it until you finish the course completely.

Nitroxoline: contraindications

The drug can not be used during pregnancy and breastfeeding, as it can provoke abnormal fetal development. Do not indulge in amateur activities and always consult a doctor before taking Nitroxoline.

Also, the drug should not be taken if you have liver and kidney disease, neuritis, cataracts. Despite the fact that it is widely used in our country, in a number of other countries it is banned. That's why we recommend not using it without consulting a specialist.

The result of taking the drug will be visible after a few days, it quickly eliminates inflammation. In addition, the course of admission is quite short - two weeks. The dosage depends on the disease, in each case it is administered individually.